Cancer Nanotechnology Symposium
Cancer Nanotechnology Symposium Overcoming Barriers to Collaboration National Cancer Institute Symposium jointly sponsored by: CASE Comprehensive Cancer Center Case Western Reserve University University Hospitals of Cleveland Ireland Cancer Center Cleveland Clinic Taussig Cancer Center InterContinental Hotel and Conference Center Cleveland, OH October 27, 2004 Introduction
If the Nation is to meet the 2015 goal of eliminating death and suffering from cancer, clinicians will need new ways to detect, treat and prevent cancer and metastases. One expectation of the field is that this era of post-genomic science, with its emphasis on genomic and proteomic analysis and systems biology, will generate unprecedented advances
Nanomedicine and Cancer
Nanotechnology has the power to radically change the way cancer is diagnosed, imaged and treated. Currently, there is a lot of research going on to design novel nanodevices capable of detecting cancer at its earliest stages, pinpointing it\'s location within the body and delivering anticancer drugs specifically to malignant cells. Nanoscale devices smaller than 50 nanometers can easily enter most cells, while those smaller than 20 nanometers can transit out of blood vessels.1 As a result, nanoscale devices can readily interact with biomolecules on both the cell surface and within the cell. Nanoscale devices are already proving that they can
Tumor-Seeking Nanoparticles
NCI Alliance for Nanotechnology in Cancer | Monthly Feature | September 2006
approximately 10 percent fail brachytherapy. Moreover, some patients experience complications such as intestinal injury, incontinence, or impotence from the radiation exposure. The Farokhzad-Langer team was interested in determining how their new nanoparticles would perform in eliminating tumors as a potential alternative to the brachytherapy approach. We wanted to see if nanoparticles could be given in one dose to produce significant tumor reduction without the complications that often accompany nonspecific radiation therapy,explained Farokhzad. For this application, the team designed customized nanoparticles that incorporated several safe or FDA-approved materials, each one
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